Understanding virus binding to cell-surface ACE2 receptors on target cells and inhibition of spike protein-receptor interactions. Expertise in receptor binding and internalization assays.
Investigating the pathological features associated with COVID-19 infection, focusing on the cytokine storm and multi-organ damage. Expertise in lung pathology models.
Exploring small molecule inhibitors of key viral proteins focusing on non-structural proteins critical for viral replication. Expertise in molecular docking and molecular dynamics simulations.
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Molecular dynamics simulations related to COVID-19.
Collection of classical antivirals, viral binding and internalisation inhibitors, interleukin and interferon inhibitors, antibiotics, steroids and other therapeutics.